Will Reshade Work with Multi Monitor?

As noted in subject, will reshade function with a multi-monitor set supporting custom resolutions?

I have been unsuccessful getting reshade to work using a configuration with multiple (3) monitors to display a 3840x1200 screen display area. I also leverage custom resolutions for the outside two monitors to allow alignment across all three screens. I would have submitted this in trouble shooting, but wanted to first field question whether reshade will work with multiple monitors and/or custom resolutions.

~S~
wind

Run your game in (borderless) window mode and stretch it across all three monitors. That yields in a single backbuffer ReShade can work with.