It's a common occurence due to the nature of how ReShade works, not the first time it happened nor will it be the last. Microsoft has been notified, expect it to be fixed with a Windows Defender definition update soon.
My antivirus software (Microsoft Defender) detects reshade 6.1.1 setup file as a virus and delete it automatically. When it will be discused with microsoft and solved? Currently i cannot use reshade 6.1.1.
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