When you're ingame and the menu of ReShade isn't open, the Ctrl+Mousewheel combination to scale the UI of ReShade still works. Pretty sure ReShade is suppose to ignore that key combination when the menu isn't open.
Changing the "Input Processing" dropdown menu to any of the 3 options has no effect on this issue.
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Ctrl+Mousewheel working when menu isn't active 7 months 3 weeks ago #2