Hi,
what game have you issues with? Some games locks/hides mouse cursor, so maybe that's the cause (i remember having this problem in Final Fantasy XV).
You can try to solve this by following this guide:
reshade.me/forum/troubleshooting/3293-co...-and-their-solutions
(scroll down to point 3, section d: "Mouse Stuck")
If it won't work you can try using your keyboard to navigate through reshade interface. Instructions on how to do that are in the tutorial that comes up the first time you install reshade. So, if you already skipped it, just go in the "settings" tab and click on "Restart Tutorial".
About using newer versions of reshade, there can be several reasons why it doesn't work. Can you provide a better description of the issue?