[Reshade Version 4.3.0] Not working The Witcher 3

So where's the thing guy's i install the newest version Reshade 4.3.0 and eveything went well untill i decide to install a reshade preset for the game i mean i cannot turn it on. I try Shift plus F2 and other sort of combinations but all in vain. In game i can open the Reshade Menu, so everything seems alright excepet i can't activet a reshade preset that i download on youtube.

Any ideas of what it could be ?

Wheres a screenshoot of my bin64x folder

i.ibb.co/60pG8J6/reshade.png

Would appreciate an answer

Shift+F2 was the combination to make reshade's interface show up in the previous version (3.x). From 4.0 the key is now "Home / Pos1" .

About the preset, this should come in handy:

Duran.te wrote:   - How to use Presets?
To load a preset, once you downloaded it, drag it in your game folder. Once in game, you need to select it from the drop down menu, located on top of ReShade's interface, in the Home tab. Make sure you have all the shaders the preset requires in your shader folder.
Also, keep in mind that presets made with outdated ReShade versions will easily not work. If so, search for another updated preset, or downgrade your ReShade version. You can download all previous versions from Mediafire: ReShade Repository .

EDIT: Thank a lot man thanks to you now its working

I can confirm! theres somoething wrong with presets, it even doesnt want to save changes and I must everytime start over

@Prodousier
You'll probably need to get permissions for the game directory.
Right click on the folder of your game > Properties > Security > Edit > Check "Full Control" for your user account.

BTW and if i want to desactivet the preset reshade that i choose how do i do it ?

@Andreas
Switch to the Settings tab and, where it says "Effect Toggle Key", set whatever keybind you like.

Duran.te wrote: @Prodousier
You'll probably need to get permissions for the game directory.
Right click on the folder of your game > Properties > Security > Edit > Check "Full Control" for your user account.

did it way before