Reshade is incredible and to make it even better I think we need better shaders to get rid of pixelation (at least better than HQ4x).
The ones found in Libretro/RetroArch, especifically XBR/XBRZ and ScaleFX (and his combination: XSoft+ScaleFX+Sharpsmoother), does a fantastic job and games from 3 decades looks like modern games.
For sure many users will love this feature included in Reshade.