Reshade not working - Guild Wars 2

So I've been running Reshade for a couple of years without issue, but this last few days i've noticed it stopped launching when I started my game. I did seem to be running an older version, but I've now updated and it still won't launch. 

Based on my experience goes:

There could be certain specific shaders that causing the game to crash or while during compling shaders, the program in question will quit very unexpectedly.

For testing purposes, just install the basic shaders, don't install anything else, see if that will work or not, if it indeed works, install everything again, then you will need to work on which specific shader or shaders is causing the game in question to crash, once you find out which ones are crashing the game, it should work with other games as well, some specific shaders, takes forever to compile, as its having problems, again, you will need to check the reshade log for more details on this.

And:

Reshade version: 5.9.2 and under seems to work the best for older games, far as overall performance is concerned, but, you can test different versions on your own time.

Lastly, when uninstalling reshade in general, there is one specific file that's still kept within the application folder, I believe its: ReshadePreset.ini.

If this file is still kept in the application folder, the overall performance might be slightly lowered, so just heads up on it, just uninstalling reshade, doesn't mean everything is uninstalled, I would just manually take out all the given files/folders that reshade installed, manually, then start out fresh.

I did very extensive testing on why reshade is crashing alot, head over to my Beyond Insane 4-Way Sli/Quad Sli thread here:

forums.guru3d.com/threads/beyond-insane-...ad-sli-tuning.425674

And within the front page, where it describes my Quad Titan Z testing/tuning results, which is on Page 95 to 105, I did alot of extensive testing on some old DX9 games on which specific shaders causing it the games to crash, it was alot of work.
 

Okay, so I'm returning to this because it seems that some days Reshade launches when I start the game, and other times it just...doesn't. And I'm really not sure what the trigger is. I've reinstalled, checked that I have the latest version...all that stuff. I even tried launching the game via the .dll file - which launched the game, but no Reshade.

I'm not a super techy person (though my daughter is so I can ask her to translate for me if there's no layman's explanation!) but I really would like to get it working reliably again, so if anyone out there knows what might be wrong I would appreciate the help.

For context, I am running Windows 10, so I'm not sure if that's the issue? My PC isn't eligible for the upgrade, so if it is, any advice on workarounds would be very much appreciated.