Certain effects flashing on and off in League

I was super excited to try out MXAO in League of Legends and it randomly flashes on and off? The fog effect does the same thing. Is it a depth buffer issue? Would that mean I'm out of luck using depth buffer reliant effects?

Sounds like it. I've heard of it happening in other games like Skyrim, too.

League of Legends is multiplayer, and since ReShade disables the depth buffer when the network is active to prevent cheating it's possible the depth buffer flickers between "allowed" and "disallowed because cheats" as the network activity changes.