1. Even if the toggle key doesn't work you can always disable the effects one by one in the configuration file. It's more work all right, but you can do it.
2. If DOF or any other effect is not to your liking you can fine-tune it yourself, that's what all those settings are for.
3. If you really don't want Reshade at all, you can always remove the files it added in your game folder and everything shall return to normal, no harm done.
You can use a feature called "HUD_MASKING". So enable it. Then go to MasterEffect folder. You have file called "mcmask". Take a screenshot of your game. Then go to MasterEffect folder. You have file called "mcmask". Draw new mask for your game. Done.
/Sorry for my poor grammar...
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