I made an account just now to reply to this and say that I was having the exact same issue (I can move the mouse just fine, but I can't click on anything in the ReShade menu.. it doesn't recognize any of my mouse clicks).
I fixed it by simply playing the game in fullscreen mode. I was playing it on fullscreen borderless windowed mode initially. And by switching to normal fullscreen mode, it allowed me to finally interact with the ReShade menu.
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