I've recently installed reshade for new vegas but It doesn't seem to be activating. Initially it wasn't installing as I already had a d3d9.dll file for use with DXVK but after taking that out and renaming the reshade one to Reshade32.dll it isn't working at all while in game
since you are using DXVK, you dont need a DLL inside the Game folder. What you need to do, is to install ReShade with the VULKAN API selected when the Setup tool asks you what API to use.