Win11 +Reshade/dll issue?

Since upgrading to Win11 I have had reshade and other DLL solutions such as vrperfkit fail on at least 50% of new game installs. Could a win11 setting be causing this? Are a lot of recent titles unwilling to trigger additional DLL files? Las game to try was Greedfall2, nada. It simply fails to activate at all. Thanks for any help you can provide. 

Further investigation shows that this may be a confluence of game-specific incompatibilities and not directly related to Win11. Out of 6 recent game purchases, Reshade and/or vrperfkit (which I mention since it is also installed via. the use of a .dll file) fail to work in 4 of them, but work fine in the other 2. I expect that was Win11 the issue the problem would be universal.
Anyone have any tips or tricks for reluctant games beyond the usual .dll renaming?
Anyone happen to have gotten this to work in Greedfall 2 yet?