Reshade Packed Exe Problem

We're using Reshade v1.0. We have a problem like that, When we pack our .exe by molebox or themida. Your DLL can not load. How we can fix that? (We tried by UPX packer its working perfectly)

That's something you should ask the developers of those two software pieces. I don't know how they work. It's possible they remove the current directory from the DLL search path for security reasons.