How to enable/disable Reshade in-game.

I am new to Reshade and to help me see the difference Reshade makes, I want to know what the shortcut key is for enabling and disabling in-game. I am testing this for the first time in Battle Chasers: Nightwar purchased through GOG. I am using the preset from: sfx.thelazy.net/games/preset/8229/
Im not sure if I am doing everything right, but I installed Reshade setting it to the exe file in the game directory and selected DX10+ and I saved the preset file from the link above at thelazy.net into the game directory folder and set the preset location in Reshade to that preset file. I appreciate any help.

Thank you very much!