ReShade.ini reloading

Hello guys. I wrote a script for GTA V, that re-writing ReShade.ini, or exactly changing the path to a used preset configuration. I wanna make unique presets for all types of weather, so need to change them automatically, when a path in ReShade.ini was re-written. Is it possible to reload this file? Maybe, there is a combination of keys for that? Thanks in advance ^^

This is not currently possible. The config is only loaded once on startup and then cached to reduce disk IO and there isn't a way to force a reload without restarting.
ReShade has the option to bind a key to switch between presets though, so if you put your presets in one folder, then you can use that to toggle through them.

Oh . _. Damn. Well, I'll try to switch presets by RS. Thanks ^^