Is it possible to activate an effect on Mouse Buttom Press/Release??

Hi!! As the tittle says, Im interested in adding DoF only while pressing my right mouse buttom in to STALKER ANOMALY game, the idea is to only have it applied when I use aim down sight on the guns. It is somehow possible?? Thanks in advance 

The game also has a "hold" funtion for ADS, so it could work also if i can bind the RMB to the DoF effect not having to use a feature like "On Press/Release", this could be an easier solution but I am unable to bind Mouse Buttoms to an effect as far as i know.

The absolute simplest way would be to bind the shader to a hotkey toggle on your keyboard that you don't use, and then write an autohotkey script that virtually presses that toggle key when you press and release the mouse button.

I don't know for sure if reshade can pickup on autohotkey's send, but that would work with reshade, but that's what I'd try.