I'm using the Mastereffect version of reshade with GZDoom and I ❤ depth of field, but it sometimes it makes the pause menu text look blurry, so I thought of making the pause button (Escape) toggle DoF. Maybe it's possible with a batch file or AutoHotKey changing Mastereffect.h, but I don't know if that's possible (and I don't know alot about using those).
I imagine you are using an older version of Reshade with only the MasterEffect suite of shaders installed. If so, I suggest you upgrade to the latest Framework version that allows to have toggle keys for every single effect that there is (including DOF, mine is mapped to the END key). Unfortunately, that means that you need to import the values from your MasterEffect.h file to the new file system either manually or by means of the Mediator interface. Imo it's worth the effort, you'll gain in performance and maybe in quality too, lots of these shaders are still in active development.