I sometimes move my games across various disks and partitions.
If I originally installed a specific Reshade preset and its location was the game directory, I try to choose preset manually because it got deleted and is no longer visible to the Reshade.
I can't, because the only disk available in the in-game Reshade window is where previously preset was.
To sum up -
The game with preset was installed on
\
>
Directory is now moved to E:\
>
Reshade allows choosing presets only from
\
I know it can be changed from config file, but someone probably stumbled on that issue before too.