Since the latest 1.10 patch for Witcher 3, Reshade no longer works, or to be more precise, the game won't run at all if the Reshade dxgi.dll is present.
It looks like Witcher 3 now has its own d3d11.dll and dxgi.dll and trying to overwtrite the dxgi.dll breaks the game.
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Problem in Witcher 3 update (1.10)
2 years 9 months ago #2