A similar issue happens with Darksiders II. The toggle key is ignored seemingly more than 50% of the time it is pressed, and the only messages I see when it works, indicate that the Frame Work is either toggled on or off. There is no message about the SweetFX/SMAA shader being toggled. The OSD text also doesn't change in appearance during the toggling which indicates that the SMAA shader isn't being applied.
The shader compiles successfully. I have a standard 101 US keyboard that uses a PS/2 connector. Windows 10 x64.
RFX_ToggleKey is "VK_PAUSE" and SMAA_ToggleKey is "RFX_ToggleKey"?
Still an issue with ReShade v188.8.131.520 and it's not just the one game I mentioned in the original topic that is plagued by this issue, it also happens with DarkSiders II (Dunno about Deathinitive Edition)