Would you post a screenshot of your mediator setup tab?
I actually assume that you dropped the files in a game folder (not separate folder). The mediator will then assume that you are going to use it locally for which profiles are not needed cause the binaries are already in place (therefore the profile section becomes hidden). Its a change in behaviour since 1.1 to not confuse people that want to use a complete/separate installation of the ReShade Framework in each single game. (this has been discussed with Marty who happened to use ReShade that way)
The only downside we have seen with this was that you need to manually rename the ReShade binaries but in our discussion this was an acceptable trade off.