After downloading the latest EXE, I receive an error when attempting to install: Reshade_Setup_3.0.3.exe is not a valid Win32 application. After re-downloading the file several times, the end result is the same. I looked over the home page for system requirements, but I do not see anything mentioning this being a 64-bit app.
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You'll need Windows 7 or higher and the .NET framework 4 or higher installed in order to run the setup tool. It should run on a 32 bit Windows too (provided the .NET framework is installed correctly), but was only tested under 64 bit Windows.