Reshade doesn't have a problem with GTX cards. I think it maybe be something else.
Sometimes Reshade doesn't play nice with overlays. Overlays like steam, rivatuner, GOG. I had some games crash before they start with those. But there is only one game in my 200+ games that doesn't work with Reshade. I have a Nvidia 960 4gb
Not sure which games game you are referring to
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