ReShade_Setup_3.0.5.exe does nothing...

I run it (I've tried with and without run as administrator), the hour glass shows up for a bit, then ... nothing... nothing at all. No error messages, no application, nothing.

Check your anti virus.

I didn't see any reports in my anti-virus. I temporarily disabled it and I am still experiencing the same result.

Then make sure you have .NET 4.5.2 installed.

I don't have .NET 4.5.2 and the installer for it won't install because I have a higher version. I find this odd because I have multiple versions of .NET installed. Is there some way around this or should it work with .NET 4.6.1?
Thank you for time and effort.

For newer Windows versions there should be two .NET installs which are version 3.x usually that's 3.5.x as a optional you can enable (Or will be prompted to enable if a program requires it.) and then also 4.x of which the latest is I think 4.6.2 currently and it replaces earlier 4.x versions completely.
(Pretty sure 4.6.2 is the default of the current Windows 10 release too and then some various security updates via these monthly cumulative updates for the OS.)