Trouble starting witcher 3

When i starting witcher 3 with reshade this stopping and i don't know why. Could you help me ?. Thank you
image

I too have this same problem, I don't know what caused it to start doing it i haven't played in some time now. When i click on the icon to play it starts then crashes. Removed all files to start fresh an still the same thing not sure what to do now. Someone have some info to share?