The original Medal of Honor
Medal of Honor Breakthrough
Medal of Honor Spearhead
They are OpenGL games and I have tried all the reshades (from 0.10 to 0.16) on them with exactly the same results.
Reshade load up to the Main Menu, but once a new game is started (you choose the difficult mode) the whole screen gets a pale grainey color through which you can't see. The only way then to continue to play the game is to disable Reshade with the ScrollLock. As soon as I enable Reshade again it is the same problem again. Maybe there is a setting in the file "Sweet.fx" itself that can be adjusted to fix this?