Using latest version of ReShade on Kingdoms of Amalur: Reckoning.
Accidentally assigned some toggle keys for some effects. Removed them all with Backspace. After game restart they are all back again.
Same thing happens when I switch between performance/configuration modes.

Whoops, nice find. Fixed in github.com/crosire/reshade/commit/ff0c0f...fc1da01a88533f1f8455.

Until that's published in a new version, you can remove the associated "Key... = ..." line in your preset file manually.