I works though, at least for me. Updated to latest version seems better than earlier two versions.
Got little to almost no screen freeze and graph reset. So far no game crashes at all so I'm pretty happy.
Altough I'm confident that this is also Blizzard's doing, in the background they bugfix this crap engine as they patch it up, weekly 2-5 times.
EDIT: Try to do a clean install again, from scratch (Reshade). And maybe latest gpu drivers with DDU for fresh cleaning the driver files.