I just bought Crysis 2 Remastered which uses Vulkan. I also got Wolfenstein II: The New Colossus installed which also uses Vulkan. No matter what I do, whether I enable the Vulkan support globally or not in Reshade menu, it does nothing. It doesn't show the menu in-game so it definitely doesn't work.
Funny thing is that I remember it working in New Colossus a long time ago. I have also played DOOM 2016 with it on.