Profiling ReShade in a game doesn't typically work because the hooks from ReShade and Nsight interfer with each other. You can however build ReShade from source and choose its "Debug App" solution configuration in Visual Studio. That will build ReShade as a standalone application, which can be profiled with Nsight Graphics (just set the Application Executable to the resulting "ReShade64.exe" and the Command Line Arguments to "-d3d12").
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