Is it possible to save selected presets as default startup state?
I'm using Adaptive Sharpen and Colorfulness but each time I'm starting the game I have to select it to run.
After restarting the game the situation repeats - I need to select them again.

Is it possible to save these two presets to be always turned on with the game by default?

They are on by default if you create a preset with those two effects enabled. Click the "+" at the top to create a preset. Then make your changes. If you leave that preset selected in the top bar it will still be the default next time you launch the game.

That works! Thank you!