I have had this issue in multiple games but most recently in Fallout 76. I have ReShade running and press the hotkeys to open the GUI and I can't move the mouse over the ReShade GUI... Its like bouncing my cursor off of something and won't allow me to get over to the check-boxes or tabs!
Am I missing something?
What is wrong?
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Random Glitch happening in certain games? 10 months 4 weeks ago #2
That also happens in Fallout 4. One way to fix it (at least in FO4) is to temporarily connect a controller. That disables the keyboard/mouse input and you can move the cursor freely when the GUI is open. No idea if that works in Fallout 76 though (probably, because creation engine...).