I wasn't sure whether I should post this on ReShade or CEMU forums but I think I'm going to have more luck here. So basically ReShade causes a massive performance drop to the WiiU emulator "CEMU" by merely being an attachment to it. What I mean by this is that ReShade kills the framerate regardless of whether the effects are enabled or not.
The game I want to run it with is Xenoblade Chronicles X and both ReShade and CEMU are updated to their latest version.
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CEMU is very experimental, I doubt you will get good performance, it's not Reshade, it's CEMU and the game itself. I prefer using older CEMUs because they seem to work better with Reshade. New CEMUs for me cause more issues and FPS drops with Reshade, only thing to do is wait for CEMU to add proper support, Reshade is open source so they can do it but most likely wont do it anytime soon since they are busy developing the emulator itself.