Using ReShade v6.4.1 with Witcher 2 (GOG) v3.5.0.26g results in keystrokes registering twice. Searched for this issue. Found
this ancient thread
describing the same problem. I had a few older versions of ReShade lying around and rolled back to those. The most recent version without the issue was v6.3.3. The problem appears to have been re-introduced in v6.4.0.
Also using an AMD RX 6700 XT with Adrenalin 25.3.1 drivers in Win10 22H2.